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In the next step, you need to enter the address ComputerHKEY_CLASSES_ROOTacrobatshellopenddeexecapplication in the address bar.Click Run, type Regedit on the empty field, and select OK.Note: Take the backup of your file before accessing the registry editor and avoid making unnecessary changes through it. Follow these steps to modify settings from the registry editor. You can resolve the ‘ Acrobat failed to connect to a DDE server’ error by changing your Windows registry settings. Also, keep in mind to not update your software to the versions that have stopped working in recent times. Update to the latest version of Adobe Acrobat software from the official website of Adobe.Go to Help and Check for updates to automatically update the Adobe Acrobat to the latest version.Note: Start by simply restarting the Adobe Acrobat software and check if it is working fine later. In order to rectify the ‘Acrobat failed to connect to a DDE server’ error, we recommend you to go through the steps discussed in the upcoming sections. There are several methods to resolve this issue in Acrobat. Several Methods To Resolve Acrobat DDE Server Connection Failed If Adobe Acrobat is set as the protected mode.Adobe Acrobat may not be updated with the latest version.If Adobe Acrobat is not installed properly, the system may still throw the error message saying ‘Acrobat failed to connect to a DDE server’.A third-party application such as an antivirus may be blocking the functioning.If the user is trying to open multiple PDF files at once by merge documents within Adobe Acrobat, this error may appear.The Adobe Acrobat PDF running on Windows may cast an error message “Acrobat failed to connect to a DDE server” for some users due to the following reasons. DDE (Dynamic Data Exchange) server transfers information between different applications in the Windows operating system and helps them to interact with the data transparently.